InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAT5A

Summary

InnateDB Protein

IDBP-599160.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT5A

Protein Name

signal transducer and activator of transcription 5A

Synonyms

MGF; STAT5;

Species

Homo sapiens

Ensembl Protein

ENSP00000443107

InnateDB Gene

IDBG-50625 (STAT5A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.

Experimentally validated
Total	123 [view]
Protein-Protein	94 [view]
Protein-DNA	29 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0000255	allantoin metabolic process
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0019530	taurine metabolic process
GO:0038161	prolactin signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0045087	innate immune response (InnateDB)
GO:0046449	creatinine metabolic process
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt