InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTN4

Summary

InnateDB Protein

IDBP-599189.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTN4

Protein Name

netrin 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000444432

InnateDB Gene

IDBG-51764 (NTN4)

Protein Structure

UniProt Annotation

Function

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. {ECO:0000269PubMed:11038171}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:11038171}. Note=Major component.

Disease Associations

Tissue Specificity

Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen. {ECO:0000269PubMed:11038171}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007411	axon guidance
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type

PFAM

PF00053
PF00055
PF01759

PRINTS

PIRSF

SMART

SM00180
SM00136
SM00643

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HB63