Version 5.4
| Homo sapiens Protein: PFN3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-59928.4 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | PFN3 | ||||||||
| Protein Name | profilin 3 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000351379 | ||||||||
| InnateDB Gene | IDBG-59926 (PFN3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis. {ECO:0000269PubMed:19419568}. | ||||||||
| Subcellular Localization | Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Testis specific. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR005454
Profilin, chordates IPR005455 Profilin |
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| PFAM |
PF00235
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| PRINTS |
PR01639
PR00392 PR01640 |
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| PIRSF | |||||||||
| SMART |
SM00392
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P60673 | ||||||||
| PhosphoSite | PhosphoSite-P60673 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 345456 | ||||||||
| UniGene | Hs.130196 | ||||||||
| RefSeq | NP_001025057 | ||||||||
| HUGO | HGNC:18627 | ||||||||
| OMIM | 612812 | ||||||||
| CCDS | CCDS34301 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC090063 BC132952 BC132954 CH471195 | ||||||||
| GenPept | AAI32953 AAI32955 EAW85006 | ||||||||