InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKAB1

Summary

InnateDB Protein

IDBP-59971.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAB1

Protein Name

protein kinase, AMP-activated, beta 1 non-catalytic subunit

Synonyms

AMPK; HAMPKb;

Species

Homo sapiens

Ensembl Protein

ENSP00000229328

InnateDB Gene

IDBG-59969 (PRKAB1)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	40 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004679	AMP-activated protein kinase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0010628	positive regulation of gene expression
GO:0050790	regulation of catalytic activity
GO:0051291	protein heterooligomerization
GO:0061024	membrane organization