InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRT4

Summary

InnateDB Protein

IDBP-600391.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRT4

Protein Name

keratin 4

Synonyms

CK-4; CK4; CYK4; K4; WSN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000448220

InnateDB Gene

IDBG-35080 (KRT4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0030855	epithelial cell differentiation
GO:0050680	negative regulation of epithelial cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005882	intermediate filament
GO:0009986	cell surface
GO:0045095	keratin filament
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
IPR003054 Keratin, type II
IPR009053 Prefoldin

PFAM

PF00038

PRINTS

PR01248
PR01276

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P19013

PhosphoSite

PhosphoSite-P19013

TrEMBL

Q9UEK9

UniProt Splice Variant

Entrez Gene

3851

UniGene

Hs.736109

RefSeq

NP_002263

HUGO

HGNC:6441

OMIM

123940

CCDS

CCDS41787

HPRD

00478

IMGT

EMBL

AC107016 AY043326 BC003630 BC042174 D50666 X07695 X61028 X67683

GenPept

AAH03630 AAH42174 AAL14196 BAA09320 CAA30534 CAA43362 CAA47914