InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP1A1

Summary

InnateDB Protein

IDBP-600567.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1A1

Protein Name

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445306

InnateDB Gene

IDBG-101377 (ATP1A1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016791	phosphatase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030506	ankyrin binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0043531	ADP binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002028	regulation of sodium ion transport
GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0008217	regulation of blood pressure
GO:0010107	potassium ion import
GO:0015672	monovalent inorganic cation transport
GO:0016311	dephosphorylation
GO:0031947	negative regulation of glucocorticoid biosynthetic process
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042493	response to drug
GO:0045822	negative regulation of heart contraction
GO:0045823	positive regulation of heart contraction
GO:0045989	positive regulation of striated muscle contraction
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071260	cellular response to mechanical stimulus
GO:0086004	regulation of cardiac muscle cell contraction

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt