InnateDB Protein
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IDBP-600587.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNTB2
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Protein Name
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syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
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Synonyms
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D16S2531E; EST25263; SNT2B2; SNT3; SNTL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000436443
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InnateDB Gene
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IDBG-38937 (SNTB2)
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Protein Structure
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Function |
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
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Subcellular Localization |
Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001478
PDZ domain
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PFAM |
PF00595
PF13180
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PRINTS |
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PIRSF |
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SMART |
SM00228
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TIGRFAMs |
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Modification |
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SwissProt |
Q13425
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PhosphoSite |
PhosphoSite-Q13425
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6645
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UniGene |
Hs.717683
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RefSeq |
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HUGO |
HGNC:11169
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OMIM |
600027
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CCDS |
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HPRD |
02491
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IMGT |
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EMBL |
AF243385
BC048215
U40572
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GenPept |
AAC50449
AAH48215
AAK15149
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