InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSHR

Summary

InnateDB Protein

IDBP-600600.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSHR

Protein Name

thyroid stimulating hormone receptor

Synonyms

CHNG1; hTSHR-I; LGR3;

Species

Homo sapiens

Ensembl Protein

ENSP00000441235

InnateDB Gene

IDBG-14472 (TSHR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004996	thyroid-stimulating hormone receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008344	adult locomotory behavior
GO:0030183	B cell differentiation
GO:0038194	thyroid-stimulating hormone signaling pathway
GO:0040012	regulation of locomotion
GO:0040018	positive regulation of multicellular organism growth

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002131 Glycoprotein hormone receptor family
IPR002272 Follicle stimulating hormone receptor
IPR002273 Lutropin-choriogonadotropic hormone receptor
IPR002274 Thyrotropin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00373
PR01143
PR01144
PR01145

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P16473