Version 5.4
Homo sapiens Gene: TSHR
Summary
InnateDB Gene IDBG-14472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSHR
Gene Name thyroid stimulating hormone receptor
Synonyms CHNG1; hTSHR-I; LGR3
Species Homo sapiens
Ensembl Gene ENSG00000165409
Encoded Proteins
IDBP-14474
thyroid stimulating hormone receptor
IDBP-14476
thyroid stimulating hormone receptor
IDBP-600600
thyroid stimulating hormone receptor
IDBP-588876
thyroid stimulating hormone receptor
IDBP-600961
thyroid stimulating hormone receptor
IDBP-586597
thyroid stimulating hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:80954989-81146302
Strand Forward strand
Band q31.1
Transcripts
ENST00000342443 ENSP00000340113
ENST00000298171 ENSP00000298171
ENST00000557096
ENST00000541158 ENSP00000441235
ENST00000553763
ENST00000555326 ENSP00000451092
ENST00000554263 ENSP00000451202
ENST00000554435 ENSP00000450549
ENST00000556031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0030183 B cell differentiation
GO:0038194 thyroid-stimulating hormone signaling pathway
GO:0040012 regulation of locomotion
GO:0040018 positive regulation of multicellular organism growth
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020963
View Gene Order
ENSBTAG00000017489
Not yet available
Pathways
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_16942
Hormone ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa05320
Autoimmune thyroid disease pathway
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.160411
RefSeq NM_000369 NM_001018036 NM_001142626 XM_005268037 XM_005268039 XM_006720245
HUGO
OMIM
CCDS CCDS32131 CCDS55935 CCDS9872
HPRD 04537
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca