InnateDB Protein
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IDBP-600797.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC25A3
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Protein Name
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solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
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Synonyms
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PHC; PTP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000448708
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InnateDB Gene
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IDBG-52270 (SLC25A3)
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Protein Structure
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Function |
Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).
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Subcellular Localization |
Mitochondrion inner membrane; Multi-pass membrane protein.
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Disease Associations |
Mitochondrial phosphate carrier deficiency (MPCD) [MIM:610773]: Fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. {ECO:0000269PubMed:17273968}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
85
[view]
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Protein-Protein |
85
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018108
Mitochondrial substrate/solute carrier
IPR023395
Mitochondrial carrier domain
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PFAM |
PF00153
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q00325
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PhosphoSite |
PhosphoSite-Q00325
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TrEMBL |
Q6MZF9
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UniProt Splice Variant |
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Entrez Gene |
5250
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UniGene |
Hs.290404
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RefSeq |
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HUGO |
HGNC:10989
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OMIM |
600370
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CCDS |
CCDS9065
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HPRD |
02654
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IMGT |
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EMBL |
AB064666
AK092689
BC000998
BC001328
BC003504
BC004345
BC006455
BC011574
BC011641
BC014019
BC015379
BC051367
BX647062
CH471054
X60036
X77337
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GenPept |
AAH00998
AAH01328
AAH03504
AAH04345
AAH06455
AAH11574
AAH11641
AAH14019
AAH15379
AAH51367
BAB93517
BAG52596
CAA42641
CAB56611
CAB56612
CAE46080
EAW97595
EAW97596
EAW97597
EAW97598
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