InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC16A7

Summary

InnateDB Protein

IDBP-601328.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC16A7

Protein Name

solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

Synonyms

MCT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000448742

InnateDB Gene

IDBG-44219 (SLC16A7)

Protein Structure

UniProt Annotation

Function

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. {ECO:0000269PubMed:9786900}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15505343, ECO:0000269PubMed:9786900}; Multi-pass membrane protein {ECO:0000269PubMed:15505343, ECO:0000269PubMed:9786900}.

Disease Associations

Tissue Specificity

Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells. {ECO:0000269PubMed:15505343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005477	pyruvate secondary active transmembrane transporter activity
GO:0015129	lactate transmembrane transporter activity
GO:0015293	symporter activity
GO:0015355	secondary active monocarboxylate transmembrane transporter activity
GO:0050833	pyruvate transmembrane transporter activity

Biological Process

GO:0015711	organic anion transport
GO:0015718	monocarboxylic acid transport
GO:0035873	lactate transmembrane transport
GO:0055085	transmembrane transport
GO:1901475	pyruvate transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004743 Monocarboxylate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60669

PhosphoSite