Version 5.4
Homo sapiens Gene: SLC16A7
Summary
InnateDB Gene IDBG-44219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A7
Gene Name solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
Synonyms MCT2
Species Homo sapiens
Ensembl Gene ENSG00000118596
Encoded Proteins
IDBP-44221
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-590381
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-601269
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-601016
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-601328
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-592768
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-591314
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-601749
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-587450
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-584358
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-598171
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-588757
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
IDBP-598079
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:59596067-59789855
Strand Forward strand
Band q14.1
Transcripts
ENST00000261187 ENSP00000261187
ENST00000552432 ENSP00000449547
ENST00000547379 ENSP00000448071
ENST00000549465 ENSP00000447555
ENST00000552024 ENSP00000448742
ENST00000548610 ENSP00000446722
ENST00000550062 ENSP00000450133
ENST00000549588
ENST00000546459 ENSP00000449229
ENST00000552405
ENST00000549033 ENSP00000447459
ENST00000551877 ENSP00000449972
ENST00000547801
ENST00000549928 ENSP00000449167
ENST00000549305 ENSP00000448870
ENST00000548444 ENSP00000447814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005477 pyruvate secondary active transmembrane transporter activity
GO:0015129 lactate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
GO:0050833 pyruvate transmembrane transporter activity
Biological Process
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0035873 lactate transmembrane transport
GO:0055085 transmembrane transport
GO:1901475 pyruvate transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020102
View Gene Order
ENSBTAG00000021287
Not yet available
Pathways
NETPATH
REACTOME
REACT_20515
Proton-coupled monocarboxylate transport pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.589104 Hs.88156
RefSeq NM_001270622 NM_001270623 NM_004731 XM_005269231 XM_006719693
HUGO
OMIM
CCDS CCDS8961
HPRD 06791
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca