InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGAM

Summary

InnateDB Protein

IDBP-601459.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGAM

Protein Name

maltase-glucoamylase (alpha-glucosidase)

Synonyms

MG; MGA;

Species

Homo sapiens

Ensembl Protein

ENSP00000447378

InnateDB Gene

IDBG-546963 (MGAM)

Protein Structure

UniProt Annotation

Function

May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.

Subcellular Localization

Apical cell membrane; Single-pass type II membrane protein. Note=Brush border.

Disease Associations

Tissue Specificity

Expressed in small intestine, granulocyte, and kidney but not in salivary gland or pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004339	glucan 1,4-alpha-glucosidase activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004558	alpha-glucosidase activity
GO:0016160	amylase activity
GO:0030246	carbohydrate binding
GO:0032450	maltose alpha-glucosidase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005983	starch catabolic process
GO:0044245	polysaccharide digestion
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000322 Glycoside hydrolase, family 31
IPR000519 P-type trefoil
IPR011013 Galactose mutarotase-like domain
IPR017853 Glycoside hydrolase, superfamily

PFAM

PF01055
PF00088

PRINTS

PIRSF

SMART

SM00018

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43451