Homo sapiens Gene: MGAM
Summary
InnateDB Gene IDBG-546963.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGAM
Gene Name maltase-glucoamylase (alpha-glucosidase)
Synonyms MG; MGA;
Species Homo sapiens
Ensembl Gene ENSG00000257335
Encoded Proteins
maltase-glucoamylase (alpha-glucosidase)
maltase-glucoamylase (alpha-glucosidase)
maltase-glucoamylase (alpha-glucosidase)
maltase-glucoamylase (alpha-glucosidase)
maltase-glucoamylase (alpha-glucosidase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59%% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141907813-142106747
Strand Forward strand
Band q34
Transcripts
ENST00000465654 ENSP00000419372
ENST00000497554
ENST00000497673 ENSP00000417103
ENST00000475668 ENSP00000417515
ENST00000495045
ENST00000490593
ENST00000485078
ENST00000549489 ENSP00000447378
ENST00000620571 ENSP00000482292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004339 glucan 1,4-alpha-glucosidase activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004558 alpha-glucosidase activity
GO:0016160 amylase activity
GO:0030246 carbohydrate binding
GO:0032450 maltose alpha-glucosidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005983 starch catabolic process
GO:0044245 polysaccharide digestion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
Disease pathway
Digestion of dietary carbohydrate pathway
Glycogen storage diseases pathway
KEGG
Galactose metabolism pathway
Starch and sucrose metabolism pathway
Carbohydrate digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E7EW87 E9PEQ5 Q8TE25
UniProt Splice Variant
Entrez Gene 8972
UniGene Hs.122785 Hs.605252 Hs.679877 Hs.679884 Hs.690406
RefSeq NM_004668 XM_006716169 XM_006716168
HUGO HGNC:7043
OMIM 154360
CCDS CCDS47727
HPRD 01104
IMGT
EMBL AC073647 AC091684 AC091742 AF432184 AF432186
GenPept AAL83559
RNA Seq Atlas 8972