InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRAS

Summary

InnateDB Protein

IDBP-601846.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRAS

Protein Name

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Synonyms

C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RASK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000452512

InnateDB Gene

IDBG-23889 (KRAS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	55 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071

PRINTS

PR00449

PIRSF

SMART

SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q71SP6

UniProt Splice Variant

Entrez Gene

3845

UniGene

Hs.734869

RefSeq

HUGO

HGNC:6407

OMIM

190070

CCDS

HPRD

01817

IMGT

EMBL

AC087239 AC092794 AF285779 EF685661 EF685662 JQ248012 M19990

GenPept

AAA52693 AAF91482 ABS10683 ABS10684 AFF18187