InnateDB Protein
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IDBP-602024.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AKR1E2
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Protein Name
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aldo-keto reductase family 1, member E2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432947
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InnateDB Gene
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IDBG-47005 (AKR1E2)
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Protein Structure
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Function |
Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Testis-specific. {ECO:0000269PubMed:12604216}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0050571
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1,5-anhydro-D-fructose reductase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR020471
Aldo/keto reductase subgroup
IPR023210
NADP-dependent oxidoreductase domain
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PFAM |
PF00248
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PRINTS |
PR00069
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PIRSF |
PIRSF000097
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JD6
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PhosphoSite |
PhosphoSite-Q96JD6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83592
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UniGene |
Hs.657944
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RefSeq |
XP_006717578
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HUGO |
HGNC:23437
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OMIM |
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CCDS |
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HPRD |
07472
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IMGT |
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EMBL |
AB040820
AB040821
AB040822
AB055603
AC091817
AF263242
BC002862
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GenPept |
AAH02862
AAK58523
BAC54565
BAC54566
BAC54567
BAC54568
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