Version 5.4
| Homo sapiens Protein: AKR1E2 | |||||
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| Summary | |||||
| InnateDB Protein | IDBP-602024.3 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | AKR1E2 | ||||
| Protein Name | aldo-keto reductase family 1, member E2 | ||||
| Synonyms | |||||
| Species | Homo sapiens | ||||
| Ensembl Protein | ENSP00000432947 | ||||
| InnateDB Gene | IDBG-47005 (AKR1E2) | ||||
| Protein Structure |
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| UniProt Annotation | |||||
| Function | Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro). {ECO:0000250}. | ||||
| Subcellular Localization | Cytoplasm {ECO:0000305}. | ||||
| Disease Associations | |||||
| Tissue Specificity | Testis-specific. {ECO:0000269PubMed:12604216}. | ||||
| Comments | |||||
| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||
| PDB ID | |||||
| InterPro |
IPR020471
Aldo/keto reductase subgroup IPR023210 NADP-dependent oxidoreductase domain |
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| PFAM |
PF00248
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| PRINTS |
PR00069
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| PIRSF |
PIRSF000097
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| SMART | |||||
| TIGRFAMs | |||||
| Post-translational Modifications | |||||
| Modification | |||||
| Cross-References | |||||
| SwissProt | Q96JD6 | ||||
| PhosphoSite | PhosphoSite-Q96JD6 | ||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | 83592 | ||||
| UniGene | Hs.657944 | ||||
| RefSeq | XP_006717578 | ||||
| HUGO | HGNC:23437 | ||||
| OMIM | |||||
| CCDS | |||||
| HPRD | 07472 | ||||
| IMGT | |||||
| EMBL | AB040820 AB040821 AB040822 AB055603 AC091817 AF263242 BC002862 | ||||
| GenPept | AAH02862 AAK58523 BAC54565 BAC54566 BAC54567 BAC54568 | ||||