InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1CA

Summary

InnateDB Protein

IDBP-60212.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1CA

Protein Name

protein phosphatase 1, catalytic subunit, alpha isozyme

Synonyms

PP-1A; PP1A; PP1alpha; PPP1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000326031

InnateDB Gene

IDBG-60210 (PPP1CA)

Protein Structure

UniProt Annotation

Function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. {ECO:0000269PubMed:17283141, ECO:0000269PubMed:21712997}.

Subcellular Localization

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 355 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	355 [view]
Protein-Protein	352 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0005979	regulation of glycogen biosynthetic process
GO:0005981	regulation of glycogen catabolic process
GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0019433	triglyceride catabolic process
GO:0030324	lung development
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048754	branching morphogenesis of an epithelial tube
GO:0051301	cell division
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0000164	protein phosphatase type 1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0042587	glycogen granule
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043204	perikaryon
GO:0070062	extracellular vesicular exosome
GO:0070688	MLL5-L complex
GO:0072357	PTW/PP1 phosphatase complex

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt