InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1CA

Summary

InnateDB Protein

IDBP-60216.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1CA

Protein Name

protein phosphatase 1, catalytic subunit, alpha isozyme

Synonyms

PP-1A; PP1A; PP1alpha; PPP1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000350974

InnateDB Gene

IDBG-60210 (PPP1CA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 355 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	355 [view]
Protein-Protein	352 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0019433	triglyceride catabolic process
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome
GO:0070688	MLL5-L complex
GO:0072357	PTW/PP1 phosphatase complex

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt