Version 5.4
Homo sapiens Protein: PAFAH1B2
Summary
InnateDB Protein IDBP-602357.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAFAH1B2
Protein Name platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Synonyms HEL-S-303;
Species Homo sapiens
Ensembl Protein ENSP00000434951
InnateDB Gene IDBG-73009 (PAFAH1B2)
Protein Structure
UniProt Annotation
Function Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:9144386}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
GO:0016239 positive regulation of macroautophagy
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P68402
PhosphoSite PhosphoSite-P68402
TrEMBL
UniProt Splice Variant
Entrez Gene 5049
UniGene Hs.743251
RefSeq NP_001171676
HUGO HGNC:8575
OMIM 602508
CCDS CCDS53715
HPRD 03940
IMGT
EMBL AK292973 AP005018 BC000398 BC019301 CH471065 CR456736 D63390 DQ836738 DQ836739 DQ836740 DQ836741 DQ836742 DQ836743 EF445007
GenPept AAH00398 AAH19301 ABI58225 ABI58226 ABI58227 ABI58228 ABI58229 ABI58230 ACA06040 BAA19917 BAF85662 CAG33017 EAW67281

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca