Homo sapiens Gene: PAFAH1B2
Summary
InnateDB Gene IDBG-73009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAFAH1B2
Gene Name platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Synonyms HEL-S-303;
Species Homo sapiens
Ensembl Gene ENSG00000168092
Encoded Proteins
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [providedby RefSeq, May 2010]
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117144267-117176894
Strand Forward strand
Band q23.3
Transcripts
ENST00000304808 ENSP00000304006
ENST00000419197 ENSP00000388742
ENST00000527958 ENSP00000435289
ENST00000529887 ENSP00000434951
ENST00000526888
ENST00000530272 ENSP00000431365
ENST00000533206
ENST00000533677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007283 spermatogenesis
GO:0007420 brain development
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0016239 positive regulation of macroautophagy
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Ether lipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt P68402
TrEMBL
UniProt Splice Variant
Entrez Gene 5049
UniGene Hs.728488 Hs.743251
RefSeq NM_001184747 NM_002572 NM_001184746 NM_001184748
HUGO HGNC:8575
OMIM 602508
CCDS CCDS53715 CCDS8380 CCDS53714 CCDS53713
HPRD 03940
IMGT
EMBL AK292973 AP005018 BC000398 BC019301 CH471065 CR456736 D63390 DQ836738 DQ836739 DQ836740 DQ836741 DQ836742 DQ836743 EF445007
GenPept AAH00398 AAH19301 ABI58225 ABI58226 ABI58227 ABI58228 ABI58229 ABI58230 ACA06040 BAA19917 BAF85662 CAG33017 EAW67281
RNA Seq Atlas 5049