InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEF1E1

Summary

InnateDB Protein

IDBP-60267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF1E1

Protein Name

eukaryotic translation elongation factor 1 epsilon 1

Synonyms

AIMP3; P18;

Species

Homo sapiens

Ensembl Protein

ENSP00000369038

InnateDB Gene

IDBG-60265 (EEF1E1)

Protein Structure

UniProt Annotation

Function

Positive modulator of ATM response to DNA damage.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15680327}. Nucleus {ECO:0000269PubMed:15680327}. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.

Disease Associations

Tissue Specificity

Down-regulated in various cancer tissues. {ECO:0000269PubMed:15680327}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	34 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0043065	positive regulation of apoptotic process
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator