Homo sapiens Gene: EEF1E1
Summary
InnateDB Gene IDBG-60265.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF1E1
Gene Name eukaryotic translation elongation factor 1 epsilon 1
Synonyms AIMP3; P18;
Species Homo sapiens
Ensembl Gene ENSG00000124802
Encoded Proteins
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:8073360-8102578
Strand Reverse strand
Band p24.3
Transcripts
ENST00000379715 ENSP00000369038
ENST00000429723 ENSP00000414363
ENST00000502429 ENSP00000427572
ENST00000507463 ENSP00000424222
ENST00000515633 ENSP00000427143
ENST00000488226 ENSP00000425577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 34 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.608403 Hs.741422
RefSeq NM_001135650 NM_004280
HUGO
OMIM
CCDS CCDS4507 CCDS47370
HPRD 10931
IMGT
EMBL
GenPept
RNA Seq Atlas