Homo sapiens Gene: EEF1E1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-60265.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | EEF1E1 | ||||||||||||||||||
Gene Name | eukaryotic translation elongation factor 1 epsilon 1 | ||||||||||||||||||
Synonyms | AIMP3; P18 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000124802 | ||||||||||||||||||
Encoded Proteins |
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
eukaryotic translation elongation factor 1 epsilon 1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 6:8073360-8102578 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p24.3 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | H0YAH9 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9521 | ||||||||||||||||||
UniGene | Hs.608403 Hs.741422 | ||||||||||||||||||
RefSeq | NM_001135650 NM_004280 | ||||||||||||||||||
HUGO | HGNC:3212 | ||||||||||||||||||
OMIM | 609206 | ||||||||||||||||||
CCDS | CCDS4507 CCDS47370 | ||||||||||||||||||
HPRD | 10931 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AL023694 AL355499 AL451187 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 9521 | ||||||||||||||||||