Version 5.4
Homo sapiens Gene: EEF1E1
Summary
InnateDB Gene IDBG-60265.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEF1E1
Gene Name eukaryotic translation elongation factor 1 epsilon 1
Synonyms AIMP3; P18
Species Homo sapiens
Ensembl Gene ENSG00000124802
Encoded Proteins
IDBP-60267
eukaryotic translation elongation factor 1 epsilon 1
IDBP-361831
eukaryotic translation elongation factor 1 epsilon 1
IDBP-483836
eukaryotic translation elongation factor 1 epsilon 1
IDBP-482865
eukaryotic translation elongation factor 1 epsilon 1
IDBP-485063
eukaryotic translation elongation factor 1 epsilon 1
IDBP-478188
eukaryotic translation elongation factor 1 epsilon 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:8073360-8102578
Strand Reverse strand
Band p24.3
Transcripts
ENST00000379715 ENSP00000369038
ENST00000429723 ENSP00000414363
ENST00000502429 ENSP00000427572
ENST00000507463 ENSP00000424222
ENST00000515633 ENSP00000427143
ENST00000488226 ENSP00000425577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 34 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001707
View Gene Order
ENSBTAG00000002534
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YAH9
UniProt Splice Variant
Entrez Gene 9521
UniGene Hs.608403 Hs.741422
RefSeq NM_001135650 NM_004280
HUGO HGNC:3212
OMIM 609206
CCDS CCDS4507 CCDS47370
HPRD 10931
IMGT
EMBL AL023694 AL355499 AL451187
GenPept
RNA Seq Atlas 9521

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca