InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBLN1

Summary

InnateDB Protein

IDBP-603131.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBLN1

Protein Name

cerebellin 1 precursor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000444651

InnateDB Gene

IDBG-30226 (CBLN1)

Protein Structure

UniProt Annotation

Function

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). {ECO:0000250}.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des- Ser1]-cerebellin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0021707	cerebellar granule cell differentiation