InnateDB Protein
|
IDBP-603150.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
OS9
|
Protein Name
|
osteosarcoma amplified 9, endoplasmic reticulum lectin
|
Synonyms
|
ERLEC2; OS-9;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000450010
|
InnateDB Gene
|
IDBG-43274 (OS9)
|
Protein Structure
|
|
Function |
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. {ECO:0000269PubMed:17932042, ECO:0000269PubMed:18264092, ECO:0000269PubMed:18417469, ECO:0000269PubMed:19084021, ECO:0000269PubMed:19346256, ECO:0000269PubMed:21172656}.
|
Subcellular Localization |
Endoplasmic reticulum lumen {ECO:0000269PubMed:18264092, ECO:0000269PubMed:18417469, ECO:0000269PubMed:19084021}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
53
[view]
|
Protein-Protein |
53
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006621
|
protein retention in ER lumen
|
GO:0016567
|
protein ubiquitination
|
GO:0030433
|
ER-associated ubiquitin-dependent protein catabolic process
|
GO:0034976
|
response to endoplasmic reticulum stress
|
GO:0042787
|
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR009011
Mannose-6-phosphate receptor binding domain
IPR012913
Glucosidase II beta subunit-like
|
PFAM |
PF07915
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q13438
|
PhosphoSite |
PhosphoSite-Q13438
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
10956
|
UniGene |
Hs.527861
|
RefSeq |
NP_001017956
|
HUGO |
HGNC:16994
|
OMIM |
609677
|
CCDS |
CCDS31844
|
HPRD |
17804
|
IMGT |
|
EMBL |
AB002805
AB002806
AC025165
AK291374
AK293435
AK296770
AK298532
AK303858
BC000532
BC007254
BC023513
CH471054
CR456791
U41635
U81031
|
GenPept |
AAB06495
AAC39523
AAH00532
AAH07254
AAH23513
BAA24362
BAA24363
BAF84063
BAG56939
BAG59349
BAG60733
BAG64798
CAG33072
EAW97045
EAW97046
EAW97047
|
|
|