Version 5.4
Homo sapiens Protein: GCOM1
Summary
InnateDB Protein IDBP-603280.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCOM1
Protein Name GRINL1A complex locus
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000432066
InnateDB Gene IDBG-13750 (GCOM1)
Protein Structure
UniProt Annotation
Function Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Cell junction {ECO:0000269PubMed:18849881, ECO:0000269PubMed:21240187}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. {ECO:0000269PubMed:15233991, ECO:0000269PubMed:20093627}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030864 cortical actin cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031674 I band
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P0CAP1
TrEMBL A0A024R5W4
UniProt Splice Variant
Entrez Gene 145781
UniGene Hs.711270
RefSeq
HUGO HGNC:26424
OMIM 614071
CCDS CCDS10162
HPRD 08091
IMGT
EMBL AC025271 AC090651 AK055535 AY207007 AY207459 AY208913 AY237639 AY331564 AY333779 AY334560 AY334561 AY334562 AY341345 AY353056 AY353057 AY353058 AY353060 BC101645 BC112148 CH471082 FJ970029
GenPept AAI01646 AAI12149 AAO39707 AAP41548 AAP41549 AAP75897 AAQ76825 AAQ76826 AAQ76827 AAQ76828 AAQ76829 AAQ76831 AAQ76832 AAQ76833 AAQ76834 AAQ76836 ADA68358 BAB70944 EAW77522 EAW77523 EAW77527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca