Homo sapiens Gene: GCOM1
Summary
InnateDB Gene IDBG-13750.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCOM1
Gene Name GRINL1A complex locus 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137878
Encoded Proteins
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
GRINL1A complex locus
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternate splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstreamstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M). [provided by RefSeq, Nov 2011] This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternate splicing results in two readthrough transcript variants that encode different isoforms. One of the readthrough variants encodes a fusion protein that shares sequence identity with each individual gene product. The other variant encodes a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct due to frameshifts relative to the downstream gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:57591908-57714745
Strand Forward strand
Band q21.3
Transcripts
ENST00000380569 ENSP00000369943
ENST00000380568 ENSP00000369942
ENST00000496627 ENSP00000436614
ENST00000460962 ENSP00000435774
ENST00000463717 ENSP00000435028
ENST00000482814 ENSP00000436922
ENST00000496101 ENSP00000434588
ENST00000471563 ENSP00000432563
ENST00000488175 ENSP00000432066
ENST00000468886 ENSP00000433702
ENST00000477282 ENSP00000434505
ENST00000484300
ENST00000569945
ENST00000587652 ENSP00000465231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030864 cortical actin cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031674 I band
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 145781
UniGene Hs.711270
RefSeq NM_001018090 NM_001018091 NM_001285900
HUGO HGNC:26424
OMIM 614071
CCDS CCDS10162 CCDS32247 CCDS42043 CCDS42044 CCDS73732
HPRD 08091
IMGT
EMBL
GenPept
RNA Seq Atlas 100820829 145781