Version 5.4
Homo sapiens Protein: MGP
Summary
InnateDB Protein IDBP-603548.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGP
Protein Name matrix Gla protein
Synonyms MGLAP; NTI;
Species Homo sapiens
Ensembl Protein ENSP00000445907
InnateDB Gene IDBG-21291 (MGP)
Protein Structure
UniProt Annotation
Function Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Subcellular Localization Secreted.
Disease Associations Keutel syndrome (KS) [MIM:245150]: Autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. {ECO:0000269PubMed:9916809}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0008147 structural constituent of bone
Biological Process
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0030154 cell differentiation
GO:0030500 regulation of bone mineralization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR002384 Osteocalcin/matrix Gla protein
PFAM PF00594
PRINTS PR00001
PR00002
PIRSF
SMART SM00069
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08493
PhosphoSite PhosphoSite-P08493
TrEMBL A0A024RAX0
UniProt Splice Variant
Entrez Gene 4256
UniGene
RefSeq NP_000891
HUGO HGNC:7060
OMIM 154870
CCDS CCDS8669
HPRD 01112
IMGT
EMBL AC007655 AK312029 AY542304 BC005272 BC070314 BC093078 BT006733 CH471094 CR450358 DQ004248 M55270 M58549 X07362 X53331
GenPept AAB53765 AAB53766 AAH05272 AAH70314 AAH93078 AAP35379 AAT08173 AAY16978 BAG34966 CAA30287 CAA37418 CAG29354 EAW96333 EAW96334

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca