Homo sapiens Gene: MGP
Summary
InnateDB Gene IDBG-21291.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGP
Gene Name matrix Gla protein
Synonyms MGLAP; NTI;
Species Homo sapiens
Ensembl Gene ENSG00000111341
Encoded Proteins
matrix Gla protein
matrix Gla protein
matrix Gla protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:14881181-14885926
Strand Reverse strand
Band p12.3
Transcripts
ENST00000228938 ENSP00000228938
ENST00000507170
ENST00000539261 ENSP00000445907
ENST00000545199 ENSP00000445436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0008147 structural constituent of bone
Biological Process
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0030154 cell differentiation
GO:0030500 regulation of bone mineralization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4256
UniGene
RefSeq NM_001190839 NM_000900
HUGO HGNC:7060
OMIM 154870
CCDS CCDS53752 CCDS8669
HPRD 01112
IMGT
EMBL
GenPept
RNA Seq Atlas 4256