InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC24A6

Summary

InnateDB Protein

IDBP-604220.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC24A6

Protein Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000450081

InnateDB Gene

IDBG-58690 (SLC24A6)

Protein Structure

UniProt Annotation

Function

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta- cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). {ECO:0000269PubMed:15060069, ECO:0000269PubMed:20018762, ECO:0000269PubMed:22829870, ECO:0000269PubMed:23056385}.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes to mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Present in pancreatic beta-cells (at protein level). {ECO:0000269PubMed:23056385}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity

Biological Process

GO:0006811	ion transport
GO:0006851	mitochondrial calcium ion transport
GO:0042593	glucose homeostasis
GO:0050796	regulation of insulin secretion
GO:0050896	response to stimulus
GO:0055085	transmembrane transport

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0032592	integral component of mitochondrial membrane