Version 5.4
Homo sapiens Gene: SLC24A6
Summary
InnateDB Gene IDBG-58690.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC24A6
Gene Name solute carrier family 24 (sodium/lithium/calcium exchanger), member 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089060
Encoded Proteins
IDBP-58692
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604212
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604213
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604217
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604218
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604220
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604223
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604225
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604226
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604227
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
IDBP-604228
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:113298759-113359493
Strand Reverse strand
Band q24.13
Transcripts
ENST00000202831 ENSP00000202831
ENST00000552014 ENSP00000447091
ENST00000552565
ENST00000550672 ENSP00000448758
ENST00000550047 ENSP00000447585
ENST00000549069 ENSP00000449519
ENST00000546737 ENSP00000450081
ENST00000553238
ENST00000551230
ENST00000548477
ENST00000549181 ENSP00000448703
ENST00000549605 ENSP00000448749
ENST00000552613 ENSP00000447502
ENST00000548186 ENSP00000449448
ENST00000549372 ENSP00000447972
ENST00000548518
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005432 calcium:sodium antiporter activity
Biological Process
GO:0006811 ion transport
GO:0006851 mitochondrial calcium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0042593 glucose homeostasis
GO:0050796 regulation of insulin secretion
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0032592 integral component of mitochondrial membrane
GO:0042383 sarcolemma
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032754
View Gene Order
ENSBTAG00000011103
Not yet available
Pathways
NETPATH
REACTOME
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.286194 Hs.577439
RefSeq NM_024959 XM_006719608
HUGO
OMIM
CCDS CCDS31909
HPRD 15354
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca