InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G1B

Summary

InnateDB Protein

IDBP-60469.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G1B

Protein Name

phospholipase A2, group IB (pancreas)

Synonyms

PLA2; PLA2A; PPLA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000312286

InnateDB Gene

IDBG-60467 (PLA2G1B)

Protein Structure

UniProt Annotation

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. {ECO:0000269PubMed:19297324}.

Subcellular Localization

Secreted {ECO:0000269PubMed:19297324}. Note=secreted from pancreatic acinar cells in its inactive form.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0032052	bile acid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0002227	innate immune response in mucosa
GO:0002446	neutrophil mediated immunity
GO:0006633	fatty acid biosynthetic process
GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0007015	actin filament organization
GO:0007165	signal transduction
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0015758	glucose transport
GO:0016042	lipid catabolic process
GO:0019370	leukotriene biosynthetic process
GO:0019731	antibacterial humoral response
GO:0030593	neutrophil chemotaxis
GO:0032431	activation of phospholipase A2 activity
GO:0032637	interleukin-8 production
GO:0032869	cellular response to insulin stimulus
GO:0035556	intracellular signal transduction
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044240	multicellular organismal lipid catabolic process
GO:0044281	small molecule metabolic process
GO:0045740	positive regulation of DNA replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046470	phosphatidylcholine metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0048146	positive regulation of fibroblast proliferation
GO:0050482	arachidonic acid secretion
GO:0050714	positive regulation of protein secretion
GO:0050778	positive regulation of immune response
GO:0050830	defense response to Gram-positive bacterium
GO:0051092	positive regulation of NF-kappaB transcription factor activity