Homo sapiens Gene: PLA2G1B
InnateDB Gene IDBG-60467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G1B
Gene Name phospholipase A2, group IB (pancreas)
Synonyms PLA2; PLA2A; PPLA2
Species Homo sapiens
Ensembl Gene ENSG00000170890
Encoded Proteins
phospholipase A2, group IB (pancreas)
phospholipase A2, group IB (pancreas)
phospholipase A2, group IB (pancreas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phospholipase A2 (EC catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008]
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:120322111-120327789
Strand Reverse strand
Band q24.31
ENST00000308366 ENSP00000312286
ENST00000423423 ENSP00000413594
ENST00000549767 ENSP00000447233
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0032052 bile acid binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0002227 innate immune response in mucosa
GO:0002446 neutrophil mediated immunity
GO:0006633 fatty acid biosynthetic process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0015758 glucose transport
GO:0016042 lipid catabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019731 antibacterial humoral response
GO:0030593 neutrophil chemotaxis
GO:0032431 activation of phospholipase A2 activity
GO:0032637 interleukin-8 production
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044240 multicellular organismal lipid catabolic process
GO:0044281 small molecule metabolic process
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046470 phosphatidylcholine metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0050482 arachidonic acid secretion
GO:0050714 positive regulation of protein secretion
GO:0050778 positive regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0030141 secretory granule
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Acyl chain remodelling of PC pathway
Acyl chain remodelling of PI pathway
Acyl chain remodelling of PS pathway
Synthesis of PA pathway
Acyl chain remodelling of PG pathway
Acyl chain remodelling of PE pathway
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
Metabolism pathway
alpha-Linolenic acid metabolism pathway
Arachidonic acid metabolism pathway
Glycerophospholipid metabolism pathway
Linoleic acid metabolism pathway
Ether lipid metabolism pathway
Vascular smooth muscle contraction pathway
Fat digestion and absorption pathway
Pancreatic secretion pathway
Fc-epsilon receptor I signaling in mast cells
UniProt Splice Variant
Entrez Gene
RefSeq NM_000928
HPRD 01396
RNA Seq Atlas