InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPAB

Summary

InnateDB Protein

IDBP-60843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPAB

Protein Name

heterogeneous nuclear ribonucleoprotein A/B

Synonyms

ABBP1; HNRPAB;

Species

Homo sapiens

Ensembl Protein

ENSP00000351108

InnateDB Gene

IDBG-60841 (HNRNPAB)

Protein Structure

UniProt Annotation

Function

Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17289661}. Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	73 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001837	epithelial to mesenchymal transition
GO:0045893	positive regulation of transcription, DNA-templated