InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAL

Summary

InnateDB Protein

IDBP-60893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAL

Protein Name

mal, T-cell differentiation protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322860

InnateDB Gene

IDBG-60885 (MAL)

Protein Structure

UniProt Annotation

Function

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015267	channel activity
GO:0016505	peptidase activator activity involved in apoptotic process
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0001766	membrane raft polarization
GO:0006915	apoptotic process
GO:0007417	central nervous system development
GO:0030154	cell differentiation
GO:0042552	myelination
GO:0045176	apical protein localization
GO:0055085	transmembrane transport

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005887	integral component of plasma membrane
GO:0016324	apical plasma membrane
GO:0045121	membrane raft