Homo sapiens Gene: MAL
Summary
InnateDB Gene IDBG-60885.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAL
Gene Name mal, T-cell differentiation protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172005
Encoded Proteins
mal, T-cell differentiation protein
mal, T-cell differentiation protein
mal, T-cell differentiation protein
mal, T-cell differentiation protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:95025677-95053996
Strand Forward strand
Band q11.1
Transcripts
ENST00000309988 ENSP00000310880
ENST00000353004 ENSP00000306568
ENST00000354078 ENSP00000304924
ENST00000349807 ENSP00000322860
ENST00000489399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0015267 channel activity
GO:0016505 peptidase activator activity involved in apoptotic process
GO:0019911 structural constituent of myelin sheath
Biological Process
GO:0001766 membrane raft polarization
GO:0006915 apoptotic process
GO:0007417 central nervous system development
GO:0030154 cell differentiation
GO:0042552 myelination
GO:0045176 apical protein localization
GO:0055085 transmembrane transport
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019898 extrinsic component of membrane
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Role of mal in rho-mediated activation of srf [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002371 NM_022438 NM_022439 NM_022440
HUGO
OMIM
CCDS CCDS2006 CCDS2007 CCDS2008 CCDS2009
HPRD 01789
IMGT
EMBL
GenPept
RNA Seq Atlas