InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAL

Summary

InnateDB Gene

IDBG-60885.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAL

Gene Name

mal, T-cell differentiation protein

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000172005

Encoded Proteins

IDBP-60887

mal, T-cell differentiation protein

IDBP-60889

mal, T-cell differentiation protein

IDBP-60891

mal, T-cell differentiation protein

IDBP-60893

mal, T-cell differentiation protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:95025677-95053996

Strand

Forward strand

Band

q11.1

Transcripts

ENST00000309988	ENSP00000310880
ENST00000353004	ENSP00000306568
ENST00000354078	ENSP00000304924
ENST00000349807	ENSP00000322860
ENST00000489399

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015267	channel activity
GO:0016505	peptidase activator activity involved in apoptotic process
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0001766	membrane raft polarization
GO:0006915	apoptotic process
GO:0007417	central nervous system development
GO:0030154	cell differentiation
GO:0042552	myelination
GO:0045176	apical protein localization
GO:0055085	transmembrane transport
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0045121	membrane raft

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027375

View Gene Order

ENSBTAG00000034586

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_002371 NM_022438 NM_022439 NM_022440

HUGO

OMIM

CCDS

CCDS2006 CCDS2007 CCDS2008 CCDS2009

HPRD

01789

IMGT

EMBL

GenPept

RNA Seq Atlas