InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCNT2

Summary

InnateDB Protein

IDBP-60910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCNT2

Protein Name

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)

Synonyms

bA360O19.2; bA421M1.1; CCAT; CTRCT13; GCNT2C; GCNT5; IGNT; II; NACGT1; NAGCT1; ULG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000368917

InnateDB Gene

IDBG-60908 (GCNT2)

Protein Structure

UniProt Annotation

Function

Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform B is expressed in lens epithelium cells. Isoform C is expressed in reticulocytes. {ECO:0000269PubMed:12424189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity

Biological Process

GO:0006486	protein glycosylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010608	posttranscriptional regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010812	negative regulation of cell-substrate adhesion
GO:0030335	positive regulation of cell migration
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0036438	maintenance of lens transparency
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade