InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPO

Summary

InnateDB Protein

IDBP-60936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPO

Protein Name

myeloperoxidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000225275

InnateDB Gene

IDBG-60932 (MPO)

Protein Structure

UniProt Annotation

Function

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subcellular Localization

Lysosome.

Disease Associations

Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269PubMed:7904599, ECO:0000269PubMed:8142659, ECO:0000269PubMed:9354683, ECO:0000269PubMed:9637725}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004601	peroxidase activity
GO:0008201	heparin binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0001878	response to yeast
GO:0002149	hypochlorous acid biosynthetic process
GO:0002679	respiratory burst involved in defense response
GO:0006952	defense response
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0009612	response to mechanical stimulus
GO:0019430	removal of superoxide radicals
GO:0032094	response to food
GO:0032496	response to lipopolysaccharide
GO:0034374	low-density lipoprotein particle remodeling
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0044130	negative regulation of growth of symbiont in host
GO:0050832	defense response to fungus
GO:0055114	oxidation-reduction process
GO:1990268	response to gold nanoparticle

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0030141	secretory granule
GO:0042582	azurophil granule
GO:0070062	extracellular vesicular exosome