InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF21

Summary

InnateDB Protein

IDBP-61151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF21

Protein Name

fibroblast growth factor 21

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000222157

InnateDB Gene

IDBG-61149 (FGF21)

Protein Structure

UniProt Annotation

Function

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. {ECO:0000269PubMed:15902306, ECO:0000269PubMed:17623664}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0010988	regulation of low-density lipoprotein particle clearance
GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046326	positive regulation of glucose import
GO:0070374	positive regulation of ERK1 and ERK2 cascade