Version 5.4
Homo sapiens Gene: FGF21
Summary
InnateDB Gene IDBG-61149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF21
Gene Name fibroblast growth factor 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105550
Encoded Proteins
IDBP-61151
fibroblast growth factor 21
IDBP-763610
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48755559-48758330
Strand Forward strand
Band q13.33
Transcripts
ENST00000222157 ENSP00000222157
ENST00000593756 ENSP00000471477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0010988 regulation of low-density lipoprotein particle clearance
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030827
View Gene Order
ENSBTAG00000011624
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
FGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt Q9NSA1
TrEMBL
UniProt Splice Variant
Entrez Gene 26291
UniGene Hs.283015 Hs.735856
RefSeq XM_005258731 NM_019113
HUGO HGNC:3678
OMIM 609436
CCDS CCDS12734
HPRD 09447
IMGT
EMBL AB021975 AY359086 BC018404 CH471177 DQ847413
GenPept AAH18404 AAQ89444 ABI75345 BAA99415 EAW52402
RNA Seq Atlas 26291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca