Version 5.4
Homo sapiens Protein: HSD17B14
Summary
InnateDB Protein IDBP-61252.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B14
Protein Name hydroxysteroid (17-beta) dehydrogenase 14
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263278
InnateDB Gene IDBG-61250 (HSD17B14)
Protein Structure
UniProt Annotation
Function Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). {ECO:0000269PubMed:17067289}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17067289}.
Disease Associations
Tissue Specificity Highly expressed in brain, placenta, liver and kidney. {ECO:0000269PubMed:10800688, ECO:0000269PubMed:17067289}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0050662 coenzyme binding
Biological Process
GO:0006706 steroid catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF01370
PF00106
PF08659
PRINTS PR00080
PR00081
PR01397
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BPX1
PhosphoSite PhosphoSite-Q9BPX1
TrEMBL
UniProt Splice Variant
Entrez Gene 51171
UniGene
RefSeq NP_057330
HUGO HGNC:23238
OMIM 612832
CCDS CCDS12736
HPRD 16801
IMGT
EMBL AF126781 AY358430 BC006283 BC006294
GenPept AAF06940 AAH06283 AAH06294 AAQ88796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca