InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPM1E

Summary

InnateDB Protein

IDBP-61525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1E

Protein Name

protein phosphatase, Mg2+/Mn2+ dependent, 1E

Synonyms

caMKN; CaMKP-N; POPX1; PP2CH;

Species

Homo sapiens

Ensembl Protein

ENSP00000312411

InnateDB Gene

IDBG-61523 (PPM1E)

Protein Structure

UniProt Annotation

Function

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0035690	cellular response to drug
GO:0035970	peptidyl-threonine dephosphorylation
GO:0051496	positive regulation of stress fiber assembly