InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAML1

Summary

InnateDB Protein

IDBP-61658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAML1

Protein Name

mastermind-like 1 (Drosophila)

Synonyms

Mam-1; Mam1;

Species

Homo sapiens

Ensembl Protein

ENSP00000292599

InnateDB Gene

IDBG-61656 (MAML1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269PubMed:11101851, ECO:0000269PubMed:11390662, ECO:0000269PubMed:12050117, ECO:0000269PubMed:15546612, ECO:0000269PubMed:17317671}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:11101851}. Note=Nuclear, in a punctate manner.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. {ECO:0000269PubMed:11101851}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042605	peptide antigen binding

Biological Process

GO:0003162	atrioventricular node development
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007219	Notch signaling pathway
GO:0010467	gene expression
GO:0010831	positive regulation of myotube differentiation
GO:0045445	myoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051149	positive regulation of muscle cell differentiation
GO:0060928	atrioventricular node cell development

Cellular Component

GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016607	nuclear speck
GO:0043231	intracellular membrane-bounded organelle