InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARID5A

Summary

InnateDB Protein

IDBP-61764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID5A

Protein Name

AT rich interactive domain 5A (MRF1-like)

Synonyms

MRF-1; MRF1; RP11-363D14;

Species

Homo sapiens

Ensembl Protein

ENSP00000350078

InnateDB Gene

IDBG-61762 (ARID5A)

Protein Structure

UniProt Annotation

Function

Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer- dependent gene expressison. {ECO:0000269PubMed:8649988}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000269PubMed:8649988}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0035066	positive regulation of histone acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter