InnateDB Protein
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IDBP-61774.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TPCN2
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Protein Name
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two pore segment channel 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000294309
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InnateDB Gene
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IDBG-61770 (TPCN2)
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Protein Structure
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Function |
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO:0000269PubMed:19387438, ECO:0000269PubMed:19620632}.
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Subcellular Localization |
Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269PubMed:19387438}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005821
Ion transport domain
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PFAM |
PF00520
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NHX9
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PhosphoSite |
PhosphoSite-Q8NHX9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
219931
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UniGene |
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RefSeq |
NP_620714
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HUGO |
HGNC:20820
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OMIM |
612163
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CCDS |
CCDS8189
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HPRD |
18218
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IMGT |
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EMBL |
AL137479
AP003071
AY029200
BC063008
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GenPept |
AAH63008
AAK31802
CAB70760
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