InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VMP1

Summary

InnateDB Protein

IDBP-61822.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VMP1

Protein Name

vacuole membrane protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262291

InnateDB Gene

IDBG-61820 (VMP1)

Protein Structure

UniProt Annotation

Function

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. {ECO:0000250, ECO:0000269PubMed:17724469}.

Subcellular Localization

Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269PubMed:17724469}; Multi- pass membrane protein {ECO:0000269PubMed:17724469}. Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269PubMed:17724469}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0007566	embryo implantation
GO:0010506	regulation of autophagy
GO:0016337	single organismal cell-cell adhesion
GO:0034329	cell junction assembly

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0000421	autophagic vacuole membrane
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane