InnateDB Protein
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IDBP-619946.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ms4a2
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Protein Name
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membrane-spanning 4-domains, subfamily A, member 2
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Synonyms
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Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000127373
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InnateDB Gene
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IDBG-146783 (Ms4a2)
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Protein Structure
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Function |
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. {ECO:0000269PubMed:19001085}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
8
[view]
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Protein-DNA |
6
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:95495
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InterPro |
IPR007237
CD20-like
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PFAM |
PF04103
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P20490
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PhosphoSite |
PhosphoSite-P20490
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TrEMBL |
B2RTF7
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UniProt Splice Variant |
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Entrez Gene |
14126
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UniGene |
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RefSeq |
NP_038544
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MGI ID |
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MGI Symbol |
Ms4a2
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OMIM |
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CCDS |
CCDS29604
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HPRD |
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IMGT |
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EMBL |
AB033617
BC139323
BC139324
CH466534
J05019
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GenPept |
AAA37601
AAI39324
AAI39325
BAA94839
EDL41433
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