Mus musculus Gene: Ms4a2
Summary
InnateDB Gene IDBG-146783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ms4a2
Gene Name membrane-spanning 4-domains, subfamily A, member 2
Synonyms Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1;
Species Mus musculus
Ensembl Gene ENSMUSG00000024680
Encoded Proteins
membrane-spanning 4-domains, subfamily A, member 2
membrane-spanning 4-domains, subfamily A, member 2
membrane-spanning 4-domains, subfamily A, member 2
membrane-spanning 4-domains, subfamily A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:11615523-11623719
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025583 ENSMUSP00000025583
ENSMUST00000164792 ENSMUSP00000127373
ENSMUST00000186978 ENSMUSP00000140628
ENSMUST00000189641 ENSMUSP00000139841
ENSMUST00000186413
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 8 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019767 IgE receptor activity
GO:0019863 IgE binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043306 positive regulation of mast cell degranulation
GO:0050663 cytokine secretion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0005768 endosome
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0032998 Fc-epsilon receptor I complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
FCERI mediated NF-kB activation pathway
Immune System pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
KEGG
Fc epsilon RI signaling pathway pathway
Asthma pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
FCERI mediated NF-kB activation pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
KEGG
Fc epsilon RI signaling pathway pathway
Asthma pathway
INOH
PID BIOCARTA
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt P20490
TrEMBL B2RTF7 Q3UNT6
UniProt Splice Variant
Entrez Gene 14126
UniGene
RefSeq NM_001276328 NM_001276329 NM_013516 XM_006526658
OMIM
CCDS CCDS29604 CCDS70936
HPRD
IMGT
MGI ID MGI:95495
MGI Symbol Ms4a2
EMBL AB033617 AC165168 AK144021 BC139323 BC139324 CH466534 J05019
GenPept AAA37601 AAI39324 AAI39325 BAA94839 BAE25661 EDL41433
RNA Seq Atlas 14126