InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkn1c

Summary

InnateDB Protein

IDBP-619953.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn1c

Protein Name

cyclin-dependent kinase inhibitor 1C (P57)

Synonyms

AL024410; CDKI; Kip2; p57(kip2); p57Kip2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128828

InnateDB Gene

IDBG-212725 (Cdkn1c)

Protein Structure

UniProt Annotation

Function

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001822	kidney development
GO:0001890	placenta development
GO:0007050	cell cycle arrest
GO:0007568	aging
GO:0030099	myeloid cell differentiation
GO:0030325	adrenal gland development
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033673	negative regulation of kinase activity
GO:0035264	multicellular organism growth
GO:0042326	negative regulation of phosphorylation
GO:0042551	neuron maturation
GO:0043010	camera-type eye development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050680	negative regulation of epithelial cell proliferation
GO:0055123	digestive system development
GO:0060065	uterus development
GO:0060669	embryonic placenta morphogenesis
GO:0071514	genetic imprinting
GO:0071901	negative regulation of protein serine/threonine kinase activity