InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Yap1

Summary

InnateDB Protein

IDBP-620148.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Yap1

Protein Name

yes-associated protein 1

Synonyms

AI325207; Yap; Yap65; Yki; Yorkie;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134007

InnateDB Gene

IDBG-133275 (Yap1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	47 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0001570	vasculogenesis
GO:0003143	embryonic heart tube morphogenesis
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0010837	regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030903	notochord development
GO:0035019	somatic stem cell maintenance
GO:0035329	hippo signaling
GO:0042127	regulation of cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046622	positive regulation of organ growth
GO:0048339	paraxial mesoderm development
GO:0048368	lateral mesoderm development
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0072091	regulation of stem cell proliferation
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:103262

InterPro

IPR001202 WW domain

PFAM

PF00397

PRINTS

PIRSF

SMART

SM00456

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G3UYA6

UniProt Splice Variant

Entrez Gene

22601

UniGene

Mm.486262

RefSeq

MGI ID

MGI Symbol

Yap1

OMIM

CCDS

HPRD

IMGT

EMBL

AC139885 CT030639

GenPept