InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Panx1

Summary

InnateDB Protein

IDBP-620313.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Panx1

Protein Name

pannexin 1

Synonyms

AI847747;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126405

InnateDB Gene

IDBG-134948 (Panx1)

Protein Structure

UniProt Annotation

Function

Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00351}. Cell junction, gap junction. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255PROSITE- ProRule:PRU00351}.

Disease Associations

Tissue Specificity

Widely expressed, including in cartilage, skin, spleen and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005243	gap junction channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015267	channel activity
GO:0022840	leak channel activity
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding
GO:0055077	gap junction hemi-channel activity
GO:0097110	scaffold protein binding

Biological Process

GO:0002931	response to ischemia
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007267	cell-cell signaling
GO:0033198	response to ATP
GO:0034214	protein hexamerization
GO:0050715	positive regulation of cytokine secretion
GO:0050717	positive regulation of interleukin-1 alpha secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032059	bleb
GO:0043234	protein complex